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Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors that bind to ShhN and break its interaction w...
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| Publicat a: | Front Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7309560/ https://ncbi.nlm.nih.gov/pubmed/32612978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00498 |
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