Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog

The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors that bind to ShhN and break its interaction w...

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Bibliografske podrobnosti
izdano v:Front Chem
Main Authors: Yun, Taikangxiang, Wang, Juan, Yang, Jun, Huang, Wenjing, Lai, Luhua, Tan, Wenfu, Liu, Ying
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309560/
https://ncbi.nlm.nih.gov/pubmed/32612978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00498
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