A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four decades of disease progression in dominantly i...

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Publicado no:Nat Med
Main Authors: Barthélemy, Nicolas R., Li, Yan, Joseph-Mathurin, Nelly, Gordon, Brian A., Hassenstab, Jason, Benzinger, Tammie. L. S., Buckles, Virginia, Fagan, Anne M., Perrin, Richard J., Goate, Alison M., Morris, John C., Karch, Celeste M., Xiong, Chengjie, Allegri, Ricardo, Mendez, Patricio Chrem, Berman, Sarah B., Ikeuchi, Takeshi, Mori, Hiroshi, Shimada, Hiroyuki, Shoji, Mikio, Suzuki, Kazushi, Noble, James, Farlow, Martin, Chhatwal, Jasmeer, Graff-Radford, Neill R., Salloway, Stephen, Schofield, Peter R., Masters, Colin L., Martins, Ralph N., O’Connor, Antoinette, Fox, Nick C., Levin, Johannes, Jucker, Mathias, Gabelle, Audrey, Lehmann, Sylvain, Sato, Chihiro, Bateman, Randall J., McDade, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309367/
https://ncbi.nlm.nih.gov/pubmed/32161412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0781-z
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