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BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease

See Rogaeva and Schmitt-Ulms (doi: 10.1093/aww201 ) for a scientific commentary on this article . The brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decli...

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Pubblicato in:Brain
Autori principali: Lim, Yen Ying, Hassenstab, Jason, Cruchaga, Carlos, Goate, Alison, Fagan, Anne M., Benzinger, Tammie L. S., Maruff, Paul, Snyder, Peter J., Masters, Colin L., Allegri, Ricardo, Chhatwal, Jasmeer, Farlow, Martin R., Graff-Radford, Neill R., Laske, Christoph, Levin, Johannes, McDade, Eric, Ringman, John M., Rossor, Martin, Salloway, Stephen, Schofield, Peter R., Holtzman, David M., Morris, John C., Bateman, Randall J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815565/
https://ncbi.nlm.nih.gov/pubmed/27521573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww200
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