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BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease

See Rogaeva and Schmitt-Ulms (doi: 10.1093/aww201 ) for a scientific commentary on this article . The brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decli...

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Publicat a:Brain
Autors principals: Lim, Yen Ying, Hassenstab, Jason, Cruchaga, Carlos, Goate, Alison, Fagan, Anne M., Benzinger, Tammie L. S., Maruff, Paul, Snyder, Peter J., Masters, Colin L., Allegri, Ricardo, Chhatwal, Jasmeer, Farlow, Martin R., Graff-Radford, Neill R., Laske, Christoph, Levin, Johannes, McDade, Eric, Ringman, John M., Rossor, Martin, Salloway, Stephen, Schofield, Peter R., Holtzman, David M., Morris, John C., Bateman, Randall J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815565/
https://ncbi.nlm.nih.gov/pubmed/27521573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww200
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