Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

IMPORTANCE: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. However, it is unclear whether CSF levels of tTau and pTau181 have...

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Dades bibliogràfiques
Publicat a:JAMA Netw Open
Autors principals: Llibre-Guerra, Jorge J., Li, Yan, Schindler, Suzanne E., Gordon, Brian A., Fagan, Anne M., Morris, John C., Benzinger, Tammie L. S., Hassenstab, Jason, Wang, Guoqiao, Allegri, Ricardo, Berman, Sarah B., Chhatwal, Jasmeer, Farlow, Martin R., Holtzman, David M., Jucker, Mathias, Levin, Johannes, Noble, James M., Salloway, Stephen, Schofield, Peter, Karch, Celeste, Fox, Nick C., Xiong, Chengjie, Bateman, Randall J., McDade, Eric
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2019
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991202/
https://ncbi.nlm.nih.gov/pubmed/31825500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.17126
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