Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

IMPORTANCE: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. However, it is unclear whether CSF levels of tTau and pTau181 have...

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Detalhes bibliográficos
Publicado no:JAMA Netw Open
Main Authors: Llibre-Guerra, Jorge J., Li, Yan, Schindler, Suzanne E., Gordon, Brian A., Fagan, Anne M., Morris, John C., Benzinger, Tammie L. S., Hassenstab, Jason, Wang, Guoqiao, Allegri, Ricardo, Berman, Sarah B., Chhatwal, Jasmeer, Farlow, Martin R., Holtzman, David M., Jucker, Mathias, Levin, Johannes, Noble, James M., Salloway, Stephen, Schofield, Peter, Karch, Celeste, Fox, Nick C., Xiong, Chengjie, Bateman, Randall J., McDade, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991202/
https://ncbi.nlm.nih.gov/pubmed/31825500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.17126
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