Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

IMPORTANCE: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. However, it is unclear whether CSF levels of tTau and pTau181 have...

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發表在:JAMA Netw Open
Main Authors: Llibre-Guerra, Jorge J., Li, Yan, Schindler, Suzanne E., Gordon, Brian A., Fagan, Anne M., Morris, John C., Benzinger, Tammie L. S., Hassenstab, Jason, Wang, Guoqiao, Allegri, Ricardo, Berman, Sarah B., Chhatwal, Jasmeer, Farlow, Martin R., Holtzman, David M., Jucker, Mathias, Levin, Johannes, Noble, James M., Salloway, Stephen, Schofield, Peter, Karch, Celeste, Fox, Nick C., Xiong, Chengjie, Bateman, Randall J., McDade, Eric
格式: Artigo
語言:Inglês
出版: American Medical Association 2019
主題:
Original Investigation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991202/
https://ncbi.nlm.nih.gov/pubmed/31825500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.17126
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