Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice

An impaired decline in blood pressure at rest is typical in people with diabetes, reflects endothelial dysfunction, and increases the risk of end-organ damage. Here we report that microRNA-204 (miR-204) promotes endothelial dysfunction and impairment in blood pressure decline during inactivity. We s...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gaddam, Ravinder Reddy, Jacobsen, Veronica Peotta, Kim, Young-Rae, Gabani, Mohanad, Jacobs, Julia S., Dhuri, Karishma, Kumar, Santosh, Kassan, Modar, Li, Qiuxia, Bahal, Raman, Roghair, Robert, Irani, Kaikobad, Vikram, Ajit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308358/
https://ncbi.nlm.nih.gov/pubmed/32572127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66786-0
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