Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Cancer stem cells (CSCs) are a class of cancer cells characterized by self-renewal, differentiation and tumorigenic potential. We previously established a model of CSCs by culturing mouse induced pluripotent stem cells (miPSCs) for four weeks in the presence of a conditioned medium (CM) of cancer ce...

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Udgivet i:Sci Rep
Main Authors: Du, Juan, Xu, Yanning, Sasada, Saki, Oo, Aung Ko Ko, Hassan, Ghmkin, Mahmud, Hafizah, Khayrani, Apriliana Cahya, Alam, Md Jahangir, Kumon, Kazuki, Uesaki, Ryo, Afify, Said M., Mansour, Hager M., Nair, Neha, Zahra, Maram H., Seno, Akimasa, Okada, Nobuhiro, Chen, Ling, Yan, Ting, Seno, Masaharu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308356/
https://ncbi.nlm.nih.gov/pubmed/32572057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66471-2
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