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Approved LXR agonists exert unspecific effects on pancreatic β-cell function
Novel agonists of the nuclear liver-X-receptor (LXR) are designed to treat metabolic disorders or cancer. The rationale to develop these new drugs is based on promising results with established LXR agonist like T0901317 and GW3965. LXRα and LXRβ are expressed in β-cells, and expression is increased...
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| Udgivet i: | Endocrine |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308254/ https://ncbi.nlm.nih.gov/pubmed/32146655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-020-02241-4 |
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