Duchenne muscular dystrophy hiPSC–derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. In the present study, when human induced pluripotent stem cells (hiPSCs) were differentiated into myoblasts, the myoblasts derived from DMD patient hiPSCs (DMD hiPSC–derived myoblasts) exhibited an identifiable DMD-relevant phe...

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Vydáno v:JCI Insight
Hlavní autoři: Sun, Congshan, Choi, In Young, Gonzalez, Yazmin I. Rovira, Andersen, Peter, Talbot, C. Conover, Iyer, Shama R., Lovering, Richard M., Wagner, Kathryn R., Lee, Gabsang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308059/
https://ncbi.nlm.nih.gov/pubmed/32343677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134287
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