Duchenne muscular dystrophy hiPSC–derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. In the present study, when human induced pluripotent stem cells (hiPSCs) were differentiated into myoblasts, the myoblasts derived from DMD patient hiPSCs (DMD hiPSC–derived myoblasts) exhibited an identifiable DMD-relevant phe...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Sun, Congshan, Choi, In Young, Gonzalez, Yazmin I. Rovira, Andersen, Peter, Talbot, C. Conover, Iyer, Shama R., Lovering, Richard M., Wagner, Kathryn R., Lee, Gabsang
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308059/
https://ncbi.nlm.nih.gov/pubmed/32343677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134287
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