Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

[Image: see text] We have previously shown that the thermolabile, cavity-creating p53 cancer mutant Y220C can be reactivated by small-molecule stabilizers. In our ongoing efforts to unearth druggable variants of the p53 mutome, we have now analyzed the effects of other cancer-associated mutations at...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Bauer, Matthias R., Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N., Ni, Xiaomin, Khan Tareque, Raysa, Fersht, Alan R., Spencer, John, Joerger, Andreas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307883/
https://ncbi.nlm.nih.gov/pubmed/31990523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00748
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