Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

[Image: see text] We have previously shown that the thermolabile, cavity-creating p53 cancer mutant Y220C can be reactivated by small-molecule stabilizers. In our ongoing efforts to unearth druggable variants of the p53 mutome, we have now analyzed the effects of other cancer-associated mutations at...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Bauer, Matthias R., Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N., Ni, Xiaomin, Khan Tareque, Raysa, Fersht, Alan R., Spencer, John, Joerger, Andreas C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307883/
https://ncbi.nlm.nih.gov/pubmed/31990523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00748
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker