Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid

Cathepsin B (CatB), a lysosomal cysteine protease, is important to brain function and may have dual utility as a peripheral biomarker of moderate-severe traumatic brain injury (TBI). The present study determined levels of pro- and mature (mat) CatB protein as well as cysteine protease activity withi...

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Vydáno v:J Neurotrauma
Hlavní autoři: Boutté, Angela M., Hook, Vivian, Thangavelu, Bharani, Sarkis, George Anis, Abbatiello, Brittany N., Hook, Gregory, Jacobsen, J. Steven, Robertson, Claudia S., Gilsdorf, Janice, Yang, Zhihui, Wang, Kevin K.W., Shear, Deborah A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2020
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307674/
https://ncbi.nlm.nih.gov/pubmed/31973644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2019.6537
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