MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4(+) T cells

T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) context. Complementarity-determining region 3 (CDR3) is the most variable part of the TCRα and -β chains, which govern...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Logunova, Nadezhda N., Kriukova, Valeriia V., Shelyakin, Pavel V., Egorov, Evgeny S., Pereverzeva, Alina, Bozhanova, Nina G., Shugay, Mikhail, Shcherbinin, Dmitrii S., Pogorelyy, Mikhail V., Merzlyak, Ekaterina M., Zubov, Vasiliy N., Meiler, Jens, Chudakov, Dmitriy M., Apt, Alexander S., Britanova, Olga V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306996/
https://ncbi.nlm.nih.gov/pubmed/32482872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003170117
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