The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for many years. The extent of such proliferation may depend on the cytokine environment, including IL-7 and T-cell receptor (TCR) “tonic” signaling...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Egorov, Evgeny S., Kasatskaya, Sofya A., Zubov, Vasiliy N., Izraelson, Mark, Nakonechnaya, Tatiana O., Staroverov, Dmitriy B., Angius, Andrea, Cucca, Francesco, Mamedov, Ilgar Z., Rosati, Elisa, Franke, Andre, Shugay, Mikhail, Pogorelyy, Mikhail V., Chudakov, Dmitriy M., Britanova, Olga V.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066563/
https://ncbi.nlm.nih.gov/pubmed/30087674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01618
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