The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for many years. The extent of such proliferation may depend on the cytokine environment, including IL-7 and T-cell receptor (TCR) “tonic” signaling...

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Main Authors: Evgeny S. Egorov, Sofya A. Kasatskaya, Vasiliy N. Zubov, Mark Izraelson, Tatiana O. Nakonechnaya, Dmitriy B. Staroverov, Andrea Angius, Francesco Cucca, Ilgar Z. Mamedov, Elisa Rosati, Andre Franke, Mikhail Shugay, Mikhail V. Pogorelyy, Dmitriy M. Chudakov, Olga V. Britanova
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-07-01
Colecção:Frontiers in Immunology
Assuntos:
aging
T cell receptor
naive T cells
immunosequencing
Rep-Seq
CDR3 repertoire
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01618/full
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