The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for many years. The extent of such proliferation may depend on the cytokine environment, including IL-7 and T-cell receptor (TCR) “tonic” signaling...

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Main Authors: Evgeny S. Egorov, Sofya A. Kasatskaya, Vasiliy N. Zubov, Mark Izraelson, Tatiana O. Nakonechnaya, Dmitriy B. Staroverov, Andrea Angius, Francesco Cucca, Ilgar Z. Mamedov, Elisa Rosati, Andre Franke, Mikhail Shugay, Mikhail V. Pogorelyy, Dmitriy M. Chudakov, Olga V. Britanova
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-07-01
Serier:Frontiers in Immunology
Fag:
aging
T cell receptor
naive T cells
immunosequencing
Rep-Seq
CDR3 repertoire
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.01618/full
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