Functionally specialized human CD4(+) T-cell subsets express physicochemically distinct TCRs

The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4(+) T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To address this issue, we used a high-throughput a...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Kasatskaya, Sofya A, Ladell, Kristin, Egorov, Evgeniy S, Miners, Kelly L, Davydov, Alexey N, Metsger, Maria, Staroverov, Dmitry B, Matveyshina, Elena K, Shagina, Irina A, Mamedov, Ilgar Z, Izraelson, Mark, Shelyakin, Pavel V, Britanova, Olga V, Price, David A, Chudakov, Dmitriy M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773335/
https://ncbi.nlm.nih.gov/pubmed/33289628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57063
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