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Functionally specialized human CD4(+) T-cell subsets express physicochemically distinct TCRs

The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4(+) T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To address this issue, we used a high-throughput a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kasatskaya, Sofya A, Ladell, Kristin, Egorov, Evgeniy S, Miners, Kelly L, Davydov, Alexey N, Metsger, Maria, Staroverov, Dmitry B, Matveyshina, Elena K, Shagina, Irina A, Mamedov, Ilgar Z, Izraelson, Mark, Shelyakin, Pavel V, Britanova, Olga V, Price, David A, Chudakov, Dmitriy M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773335/
https://ncbi.nlm.nih.gov/pubmed/33289628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57063
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