MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4(+) T cells

T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) context. Complementarity-determining region 3 (CDR3) is the most variable part of the TCRα and -β chains, which govern...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Logunova, Nadezhda N., Kriukova, Valeriia V., Shelyakin, Pavel V., Egorov, Evgeny S., Pereverzeva, Alina, Bozhanova, Nina G., Shugay, Mikhail, Shcherbinin, Dmitrii S., Pogorelyy, Mikhail V., Merzlyak, Ekaterina M., Zubov, Vasiliy N., Meiler, Jens, Chudakov, Dmitriy M., Apt, Alexander S., Britanova, Olga V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306996/
https://ncbi.nlm.nih.gov/pubmed/32482872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003170117
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