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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory...
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| Publicado no: | Nat Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7306053/ https://ncbi.nlm.nih.gov/pubmed/32042174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0588-8 |
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