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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory...

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Bibliografiske detaljer
Udgivet i:Nat Neurosci
Main Authors: Wang, Fei, Ren, Shu-Yu, Chen, Jing-Fei, Liu, Kun, Li, Rui-Xue, Li, Zhi-Fang, Hu, Bo, Niu, Jian-Qin, Xiao, Lan, Chan, Jonah R., Mei, Feng
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306053/
https://ncbi.nlm.nih.gov/pubmed/32042174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0588-8
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