Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Severe cognitive decline is a hallmark of Alzheimer’s disease (AD). In addition to grey matter loss, significant white matter pathology has been identified in AD patients. Here, we characterized the dynamics of myelin generation and loss in the APP/PS1 mouse model of AD. Unexpectedly, we observed a...

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Publicado no:Neuron
Main Authors: Chen, Jing-Fei, Liu, Kun, Hu, Bo, Li, Rong-Rong, Xin, Wendy, Chen, Hao, Wang, Fei, Chen, Lin, Li, Rui-Xue, Ren, Shu-Yu, Xiao, Lan, Chan, Jonah R., Mei, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298291/
https://ncbi.nlm.nih.gov/pubmed/34102111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.05.012
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