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Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
Cells reinforce adhesion strength and cytoskeleton anchoring in response to the actomyosin force. The mechanical stretching of talin, which exposes cryptic vinculin-binding sites, triggers this process. The binding of RIAM to talin could regulate this mechanism. However, the mechanosensitivity of th...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7305319/ https://ncbi.nlm.nih.gov/pubmed/32561773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16922-1 |
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