Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling

Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC lo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lin, Kun-Yang, Wang, Wen-Der, Lin, Chi-Hung, Rastegari, Elham, Su, Yu-Han, Chang, Yu-Tzu, Liao, Yung-Feng, Chang, Yi-Chieh, Pi, Haiwei, Yu, Bo-Yi, Chen, Shu-Hwa, Lin, Chung-Yen, Lu, Mei-Yeh, Su, Tsu-Yi, Tzou, Fei-Yang, Chan, Chih-Chiang, Hsu, Hwei-Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305233/
https://ncbi.nlm.nih.gov/pubmed/32561720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16858-6
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