Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling

Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC lo...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Lin, Kun-Yang, Wang, Wen-Der, Lin, Chi-Hung, Rastegari, Elham, Su, Yu-Han, Chang, Yu-Tzu, Liao, Yung-Feng, Chang, Yi-Chieh, Pi, Haiwei, Yu, Bo-Yi, Chen, Shu-Hwa, Lin, Chung-Yen, Lu, Mei-Yeh, Su, Tsu-Yi, Tzou, Fei-Yang, Chan, Chih-Chiang, Hsu, Hwei-Jan
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2020
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305233/
https://ncbi.nlm.nih.gov/pubmed/32561720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16858-6
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