Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling

Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC lo...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Lin, Kun-Yang, Wang, Wen-Der, Lin, Chi-Hung, Rastegari, Elham, Su, Yu-Han, Chang, Yu-Tzu, Liao, Yung-Feng, Chang, Yi-Chieh, Pi, Haiwei, Yu, Bo-Yi, Chen, Shu-Hwa, Lin, Chung-Yen, Lu, Mei-Yeh, Su, Tsu-Yi, Tzou, Fei-Yang, Chan, Chih-Chiang, Hsu, Hwei-Jan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305233/
https://ncbi.nlm.nih.gov/pubmed/32561720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16858-6
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