Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of oocytes and viability of embryos. To understand the pathology and mechanisms associated with low mtDNA copy numbers, we knocked down mitochondrial transcription factor A (tfam),...

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Bibliografische gegevens
Gepubliceerd in:Front Cell Dev Biol
Hoofdauteurs: Otten, Auke B. C., Kamps, Rick, Lindsey, Patrick, Gerards, Mike, Pendeville-Samain, Hélène, Muller, Marc, van Tienen, Florence H. J., Smeets, Hubert J. M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Cell and Developmental Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303330/
https://ncbi.nlm.nih.gov/pubmed/32596237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00381
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