Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy

BACKGROUND: Myopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is heteroplasmic with varying mutation loads between tissues of an individual. Exerc...

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Detalles Bibliográficos
Publicado en:Stem Cell Res Ther
Autores principales: van Tienen, Florence, Zelissen, Ruby, Timmer, Erika, van Gisbergen, Marike, Lindsey, Patrick, Quattrocelli, Mattia, Sampaolesi, Maurilio, Mulder-den Hartog, Elvira, de Coo, Irenaeus, Smeets, Hubert
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925445/
https://ncbi.nlm.nih.gov/pubmed/31864395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1510-8
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