Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ∼25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next-generation sequencing to detect point mutations directly in the mtDNA of 3–15 individual mature oocytes and three somatic tissues from e...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Otten, Auke B. C., Stassen, Alphons P. M., Adriaens, Michiel, Gerards, Mike, Dohmen, Richard G. J., Timmer, Adriana J., Vanherle, Sabina J. V., Kamps, Rick, Boesten, Iris B. W., Vanoevelen, Jo M., Muller, Marc, Smeets, Hubert J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2016
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161276/
https://ncbi.nlm.nih.gov/pubmed/27770035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.194035
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