Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ∼25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next-generation sequencing to detect point mutations directly in the mtDNA of 3–15 individual mature oocytes and three somatic tissues from e...

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發表在:Genetics
Main Authors: Otten, Auke B. C., Stassen, Alphons P. M., Adriaens, Michiel, Gerards, Mike, Dohmen, Richard G. J., Timmer, Adriana J., Vanherle, Sabina J. V., Kamps, Rick, Boesten, Iris B. W., Vanoevelen, Jo M., Muller, Marc, Smeets, Hubert J. M.
格式: Artigo
語言:Inglês
出版: Genetics Society of America 2016
主題:
Investigations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161276/
https://ncbi.nlm.nih.gov/pubmed/27770035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.194035
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