Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ∼25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next-generation sequencing to detect point mutations directly in the mtDNA of 3–15 individual mature oocytes and three somatic tissues from e...

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Detalles Bibliográficos
Publicado en:Genetics
Main Authors: Otten, Auke B. C., Stassen, Alphons P. M., Adriaens, Michiel, Gerards, Mike, Dohmen, Richard G. J., Timmer, Adriana J., Vanherle, Sabina J. V., Kamps, Rick, Boesten, Iris B. W., Vanoevelen, Jo M., Muller, Marc, Smeets, Hubert J. M.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2016
Assuntos:
Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161276/
https://ncbi.nlm.nih.gov/pubmed/27770035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.194035
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