Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer

Due to its regulation of CDK1/2 phosphorylation, WEE1 plays essentially roles in the regulations of G2/M checkpoint and DNA damage response (DDR). WEE1 inhibition can increase genomic instability by inducing replication stress and G2/M checkpoint inactivation, which result in increased cellular sens...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Ha, Dong-Hyeon, Min, Ahrum, Kim, Seongyeong, Jang, Hyemin, Kim, So Hyeon, Kim, Hee-Jun, Ryu, Han Suk, Ku, Ja-Lok, Lee, Kyung-Hun, Im, Seock-Ah
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303169/
https://ncbi.nlm.nih.gov/pubmed/32555285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66018-5
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