Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells

INTRODUCTION: Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has been found to have therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those with deficiencies in the homologous recombination repair (HRR) pathway. Histone deacetylases...

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Bibliografiske detaljer
Udgivet i:Breast Cancer Res
Main Authors: Min, Ahrum, Im, Seock-Ah, Kim, Debora Keunyoung, Song, Sang-Hyun, Kim, Hee-Jun, Lee, Kyung-Hun, Kim, Tae-Yong, Han, Sae-Won, Oh, Do-Youn, Kim, Tae-You, O’Connor, Mark J, Bang, Yung-Jue
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425881/
https://ncbi.nlm.nih.gov/pubmed/25888415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0534-y
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