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Conformational dynamics of AcrA govern multidrug efflux pump assembly

Multidrug efflux pumps of pathogenic, Gram-negative bacteria comprise an innate resistance mechanism and are key contributors to the emerging global pandemic of antibiotic resistance. Several increasingly detailed cryo-electron microscopy maps have been resolved of an entire efflux pump complex, Acr...

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Bibliografiske detaljer
Udgivet i:ACS Infect Dis
Main Authors: Hazel, Anthony J., Abdali, Narges, Leus, Inga V., Parks, Jerry M., Smith, Jeremy C., Zgurskaya, Helen I., Gumbart, James C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301636/
https://ncbi.nlm.nih.gov/pubmed/31517484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00273
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