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Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA
The overexpression of multidrug efflux pumps is an important mechanism of clinical resistance in Gram-negative bacteria. Recently, four small molecules were discovered that inhibit efflux in Escherichia coli and interact with the AcrAB-TolC efflux pump component AcrA. However, the binding site(s) fo...
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| 出版年: | Biophys J |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6382954/ https://ncbi.nlm.nih.gov/pubmed/30691677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.01.010 |
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