Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA

The overexpression of multidrug efflux pumps is an important mechanism of clinical resistance in Gram-negative bacteria. Recently, four small molecules were discovered that inhibit efflux in Escherichia coli and interact with the AcrAB-TolC efflux pump component AcrA. However, the binding site(s) fo...

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Vydáno v:Biophys J
Hlavní autoři: Darzynkiewicz, Zbigniew M., Green, Adam T., Abdali, Narges, Hazel, Anthony, Fulton, Ronnie L., Kimball, Joseph, Gryczynski, Zygmunt, Gumbart, James C., Parks, Jerry M., Smith, Jeremy C., Zgurskaya, Helen I.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382954/
https://ncbi.nlm.nih.gov/pubmed/30691677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.01.010
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