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H-Bond Surrogate-Stabilized Shortest Single-Turn α-Helices: sp(2) Constraints and Residue Preferences for the Highest α-Helicities

[Image: see text] Short α-helical sequences of proteins fail to maintain their native conformation when taken out of their protein context. Several covalent constraints have been designed, including the covalent H-bond surrogate (HBS)—where a peptide backbone i + 4 → i H-bond is replaced by a covale...

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Foilsithe in:ACS Omega
Main Authors: Pal, Sunit, Banerjee, Shreya, Kumar, Ankur, Prabhakaran, Erode N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2020
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301546/
https://ncbi.nlm.nih.gov/pubmed/32566857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c01277
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