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Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin

Concomitant treatment with deferoxamine (DFO) protects neural cells from iron and heme-mediated oxidative injury, but also disrupts cell responses to iron loading that may be protective. We hypothesized that DFO treatment and withdrawal would subsequently increase neuronal vulnerability to hemoglobi...

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Pubblicato in:Exp Cell Res
Autori principali: Peng, Denggao, Chen, Cindy Acon, Ruhela, Deepa, Li, Yang, Regan, Raymond F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301423/
https://ncbi.nlm.nih.gov/pubmed/32112801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2020.111926
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