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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Genome editing holds promise for correcting pathogenic mutations. However, it is difficult to determine off-target effects of editing due to single-nucleotide polymorphism in individuals. Here we developed a method named GOTI (genome-wide off-target analysis by two-cell embryo injection) to detect o...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7301308/ https://ncbi.nlm.nih.gov/pubmed/30819928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9973 |
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