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Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
Deaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investiga...
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| Vydáno v: | Commun Biol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952419/ https://ncbi.nlm.nih.gov/pubmed/31925293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0745-3 |
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