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Simultaneous targeting of linked loci in mouse embryos using base editing
A particular challenge in genome engineering has been the simultaneous introduction of mutations into linked (located on the same chromosome) loci. Although CRISPR/Cas9 has been widely used to mutate individual sites, its application in simultaneously targeting of linked loci is limited as multiple...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6367434/ https://ncbi.nlm.nih.gov/pubmed/30733567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33533-5 |
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