Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice

The zinc finger protein CTCF has been invoked in establishing boundaries between genes, thereby controlling spatial and temporal enhancer activities. However, there is limited genetic evidence to support the concept that these boundaries restrict the search space of enhancers. We have addressed this...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Lee, Hye Kyung, Willi, Michaela, Wang, Chaochen, Yang, Chul Min, Smith, Harold E., Liu, Chengyu, Hennighausen, Lothar
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416830/
https://ncbi.nlm.nih.gov/pubmed/28334928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx185
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