CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

Although CRISPR/Cas9 genome editing has provided numerous opportunities to interrogate the functional significance of any given genomic site, there is a paucity of data on the extent of molecular scars inflicted on the mouse genome. Here we interrogate the molecular consequences of CRISPR/Cas9-media...

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Publicado no:Nat Commun
Main Authors: Shin, Ha Youn, Wang, Chaochen, Lee, Hye Kyung, Yoo, Kyung Hyun, Zeng, Xianke, Kuhns, Tyler, Yang, Chul Min, Mohr, Teresa, Liu, Chengyu, Hennighausen, Lothar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460021/
https://ncbi.nlm.nih.gov/pubmed/28561021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15464
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