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GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos
Genome editing holds great potential for correcting pathogenic mutations. We developed a method named GOTI (genome-wide off-target analysis by two-cell embryo injection) to detect off-target mutations by editing one blastomere of two-cell mouse embryos using either CRISPR-Cas9 or base editors. GOTI...
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| Veröffentlicht in: | Nat Protoc |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8190672/ https://ncbi.nlm.nih.gov/pubmed/32796939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-020-0361-1 |
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