GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

Genome editing holds great potential for correcting pathogenic mutations. We developed a method named GOTI (genome-wide off-target analysis by two-cell embryo injection) to detect off-target mutations by editing one blastomere of two-cell mouse embryos using either CRISPR-Cas9 or base editors. GOTI...

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發表在:Nat Protoc
Main Authors: Zuo, Erwei, Sun, Yidi, Wei, Wu, Yuan, Tanglong, Ying, Wenqin, Sun, Hao, Yuan, Liyun, Steinmetz, Lars M., Li, Yixue, Yang, Hui
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190672/
https://ncbi.nlm.nih.gov/pubmed/32796939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-020-0361-1
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