Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors

Base editing installs a precise nucleotide change in specific gene loci without causing a double-strand break. Its efficiency in human embryos is generally low, limiting its utility in functional genetic studies. Here, we report that injecting base editors into human cleaving two-cell and four-cell...

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Vydáno v:Genome Biol
Hlavní autoři: Zhang, Meiling, Zhou, Changyang, Wei, Yu, Xu, Chunlong, Pan, Hong, Ying, Wenqin, Sun, Yidi, Sun, Yun, Xiao, Qingquan, Yao, Ning, Zhong, Wanxia, Li, Yun, Wu, Keliang, Yuan, Gao, Mitalipov, Shoukhrat, Chen, Zi-jiang, Yang, Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532253/
https://ncbi.nlm.nih.gov/pubmed/31118069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1703-6
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