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Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors
Base editing installs a precise nucleotide change in specific gene loci without causing a double-strand break. Its efficiency in human embryos is generally low, limiting its utility in functional genetic studies. Here, we report that injecting base editors into human cleaving two-cell and four-cell...
שמור ב:
| הוצא לאור ב: | Genome Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
BioMed Central
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6532253/ https://ncbi.nlm.nih.gov/pubmed/31118069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1703-6 |
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