Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the knowledge on the maturation of the processes relevant...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Basu, Sumit, Lien, Yi Ting (Kayla), Vozmediano, Valvanera, Schlender, Jan-Frederik, Eissing, Thomas, Schmidt, Stephan, Niederalt, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300301/
https://ncbi.nlm.nih.gov/pubmed/32595502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00868
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