Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs for clinical organ xenotransplantation because many humans have minimal or no natural antibody to TKO pig cells. However, Old World monkeys (OWMs) have naturally-existing antibodies directe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yamamoto, Takayuki, Iwase, Hayato, Patel, Diyan, Jagdale, Abhijit, Ayares, David, Anderson, Douglas, Eckhoff, Devin E., Cooper, David K. C., Hara, Hidetaka
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300119/
https://ncbi.nlm.nih.gov/pubmed/32555507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66311-3
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