Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs for clinical organ xenotransplantation because many humans have minimal or no natural antibody to TKO pig cells. However, Old World monkeys (OWMs) have naturally-existing antibodies directe...

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Vydáno v:Sci Rep
Hlavní autoři: Yamamoto, Takayuki, Iwase, Hayato, Patel, Diyan, Jagdale, Abhijit, Ayares, David, Anderson, Douglas, Eckhoff, Devin E., Cooper, David K. C., Hara, Hidetaka
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300119/
https://ncbi.nlm.nih.gov/pubmed/32555507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66311-3
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