Rational development of a high-affinity secretin receptor antagonist

The secretin receptor is a prototypic class B GPCR with substantial and broad pharmacologic importance. The aim of this project was to develop a high affinity selective antagonist as a new and important pharmacologic tool and to aid stabilization of this receptor in an inactive conformation for ulti...

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Detaylı Bibliyografya
Yayımlandı:Biochem Pharmacol
Asıl Yazarlar: Dong, Maoqing, Harikumar, Kaleeckal G., Raval, Sweta R., Milburn, Juliana E., Clark, Carolyn, Alcala-Torano, Rafael, Mobarec, Juan C., Reynolds, Christopher A., Ghirlanda, Giovanna, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299832/
https://ncbi.nlm.nih.gov/pubmed/32217097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.113929
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