Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

Down syndrome (DS) is the most common genetic cause of intellectual disability. Protein homeostasis is essential for normal brain function, but little is known about its role in DS pathophysiology. In this study, we found that the integrated stress response (ISR)–a signaling network that maintains p...

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Udgivet i:Science
Main Authors: Zhu, Ping Jun, Khatiwada, Sanjeev, Cui, Ya, Reineke, Lucas C., Dooling, Sean W., Kim, Jean J., Li, Wei, Walter, Peter, Costa-Mattioli, Mauro
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299149/
https://ncbi.nlm.nih.gov/pubmed/31727829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw5185
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