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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
Down syndrome (DS) is the most common genetic cause of intellectual disability. Protein homeostasis is essential for normal brain function, but little is known about its role in DS pathophysiology. In this study, we found that the integrated stress response (ISR)–a signaling network that maintains p...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7299149/ https://ncbi.nlm.nih.gov/pubmed/31727829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw5185 |
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