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Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice
BACKGROUND: Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations. MET...
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| Publicado no: | Alzheimers Res Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6805349/ https://ncbi.nlm.nih.gov/pubmed/31639062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0540-x |
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